THURSDAY, Oct. 26, 2017 (HealthDay News) — Planning to have open heart surgery anytime soon? You might want to ask your cardiologist to book an afternoon slot inside the OR.
brand new research shows in which heart operations performed inside the afternoon produced better outcomes than those done inside the morning.
Because afternoon heart surgery syncs with the body’s circadian clock (the internal body clock in which controls when people sleep, eat as well as wake up), in which reduces the risk of heart damage, the French researchers said.
“Currently, there are few additional surgical options to reduce the risk of post-surgery heart damage, meaning brand new techniques to protect patients are needed,” said study author Dr. David Montaigne, a professor at the University of Lille.
In one part of the study, his team tracked the medical records of nearly 0 people who had heart valve replacement surgery for 500 days, to identify any major cardiac events such as a heart attack, heart failure or death coming from heart disease. Half had surgery inside the morning while the additional half had in which inside the afternoon.
The risk of a major cardiac event was 50 percent lower among patients who had surgery inside the afternoon than in those who had surgery inside the morning. in which would certainly work out to one less major cardiac event per 11 patients who have afternoon surgery, the researchers said.
In another part of the study, the researchers monitored the health of 88 heart valve replacement surgery patients until they left the hospital. During the average follow-up of 12 days, patients who had afternoon surgery had less heart tissue damage than those who had morning surgery.
The researchers then tested 30 heart tissue samples coming from in which group of patients as well as found in which samples coming from afternoon surgery patients more quickly regained their ability to contract when put in conditions in which replicated the heart refilling with blood.
Genetic analysis of the heart tissue samples also revealed in which 287 genes linked to the circadian clock were more active inside the samples coming from afternoon surgery patients than those coming from morning surgery patients.
in which suggests in which the heart is usually affected by the circadian clock, as well as in which open heart surgery outcomes reflect the heart’s poorer ability to repair inside the morning, the researchers said.
The findings were published Oct. 26 in The Lancet medical journal.
“Our study found in which post-surgery heart damage is usually more common among people who have heart surgery inside the morning, compared to the afternoon,” Montaigne said in a journal news Discharge.
“Our findings suggest in which is usually because part of the biological mechanism behind the damage is usually affected by a person’s circadian clock, as well as the underlying genes in which control in which. As a result, moving heart surgery to the afternoon may help to reduce a person’s risk of heart damage after surgery,” he added.
Montaigne as well as his colleagues also said in which may be possible to develop drugs in which can influence circadian clock-related genes to protect the heart during surgery.
— Robert Preidt
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SOURCE: The Lancet, news Discharge, Oct. 26, 2017
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