When This specific Comes to Obesity, Genes Just Partly to Blame

News Picture: When This specific Comes to Obesity, Genes Just Partly to BlameBy Dennis Thompson
HealthDay Reporter

Latest Diet & Weight Management News

THURSDAY, Oct. 26, 2017 (HealthDay News) — If you have trouble keeping slim, don’t put all the blame on your DNA.

People carrying so-called “obesity” genes tend to gain more weight if they don’t work out or don’t get enough sleep, said Timothy Frayling, a professor with the University of Exeter Medical School in England.

“You can’t change your genes — yet they only explain part of your weight,” Frayling said. This specific means of which even people genetically inclined to pile on pounds can curb This specific by eating right in addition to exercising.

Frayling in addition to his fellow researchers tracked physical activity in addition to sleep patterns for about 85,000 people in England, aged 40 to 70. The participants wore accelerometers of which allowed researchers to estimate their amount of exercise in addition to quality of sleep.

The team also computed a genetic risk score for each person based on 76 common variants known to be associated with increased risk for obesity.

Genetics accounted for some, yet not all, of a person’s obesity risk, the researchers concluded.

For example, a person of average height who had 10 genetic risk factors for obesity gained an average of 8 pounds during the course of their life if they tended to be couch potatoes, yet only about 6 pounds if they were more physically active, the study authors said.

The results were similar regarding sleeplessness. People with some genetic risk for obesity tended to have a higher body mass index (BMI) if they woke frequently or slept more restlessly, the study findings showed. BMI can be a measurement of body fat based on height in addition to weight.

“For public health in addition to diet in addition to exercise interventions, our study suggests there will be ‘bigger bang for the buck’ by focusing limited resources on people who are most susceptible due to their genes in addition to their lifestyles,” Frayling said.

Obesity experts said the study results make sense, given what’s known about the factors of which contribute to excess weight.

“Obesity can be an energy storage disease of which can be caused by hormonal imbalances,” said Dr. Mitchell Roslin, chief of obesity surgery at Lenox Hill Hospital in fresh York City. “Your genetic makeup plays a role, yet your activity in addition to the environment also influence your genetic expression,” he explained.

“Many believe of which obesity can be an epigenetic disease, meaning This specific can be not the genes themselves yet how the environment improvements their shape,” Roslin continued. “Think of genes as pieces in a jigsaw puzzle. The environment puts the puzzle together. Our actions matter, in addition to while our genes influence our behavior, our behavior influences how genes work in addition to their effect on the body.”

Dr. Jamie Kane, chairman of the Center for Weight Management at Northwell Health’s Syosset Hospital in Syosset, N.Y., said the study “seems to ring true based on the research of which’s out there to date, in addition to based on my clinical experience as well.”

Kane in addition to his staff try “to look at the lifestyle, in addition to work at the most stringent level with patients because we don’t know who has what genetics,” he said.

This specific might require more dedication, yet a person can overcome genetics of which might otherwise lead to obesity, Kane concluded.

“There are a very modest number of people who suffer by morbid obesity where This specific’s purely genetic,” he said. “In most of these cases, people might need to exercise way more than the average person, in addition to they might need to change their diet dramatically.”

Frayling in addition to his colleagues presented their findings This specific week at the annual meeting of the American Society of Human Genetics, in Orlando, Fla. Research presented at meetings should be viewed as preliminary until published in a peer-reviewed journal.

Copyright © 2017 HealthDay. All rights reserved.

SOURCES: Timothy Frayling, Ph.D., professor, University of Exeter Medical School, Exeter, England; Mitchell Roslin, M.D., chief, obesity surgery, Lenox Hill Hospital, fresh York City; Jamie Kane, M.D., chairman, Center for Weight Management, Syosset Hospital, Syosset, N.Y.; presentation, Oct. 20, 2017, annual meeting, American Society of Human Genetics, Orlando

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